What is regenerative medicine?

Regenerative medicine is the exciting cutting-edge “medicine of the future” which holds the hope & the promise of efficacy which revolves around the ability of human tissue to be repaired, replaced, and healed (regenerated) once human tissues and organs are damaged or diseased. Regenerative therapies aid and supplement the natural healing mechanisms of the body. These therapies often employ the activation of stem cells to stimulate renewal of tissue damaged by injury, disease, or age. The rapid expansion of scientific knowledge offers great promise for continuing advances in this field of medicine which holds vast potential to improve the quality of human life.

 

What are stem cells?

Stem cells are the basic building blocks of life. They are unspecialized cells that can produce more stem cells through mitosis or differentiate into specialized cells that carry out specific functions in the body. Stem cells are found throughout the body’s tissues, organs, and systems although usually in small quantities in adults.

 

What are hematopoietic stem cells?

Hematopoietic stem cells (HSCs) can give rise to all types of blood cells including red blood cells, white blood cells, and platelets. They are particularly useful in the treatment of blood-related diseases and conditions.

 

What are mesenchymal stem cells?

Mesenchymal Stem Cells (MSCs) are multipotent stromal cells that are non-blood forming stem cells and can differentiate into a variety of cell types including muscle, bone, cartilage, and fat cells.

 

When introduced into a patient’s body, MSCs can repair or replace damaged or degenerating tissue by communicating with the surrounding cells thus causing a cellular cascade of healing (paracrine signaling).

 

Historically, the term MSC was coined in the late 80’s by the biomedical research authority, Dr. Arnold Caplan of Case Western Reserve. The acronym has recently been redefined by Caplan to “Medicinal Signaling Cell” since these cells secrete powerful bioactive molecules involved in cellular signaling and regeneration. Caplan now describes MSCs as a “multisite-regulatory dispensary” (Natural Drug Store).

 

The production of MSCs in the human body, can be precipitated by bioactive placental tissues containing Growth Factors, Cytokins and other powerful bioactive agents which trigger cell signaling.

 

The remarkable ability of MSCs make them irreplaceable in medical treatments.

 

What are accessible sources of stem cells?

Stem cells can be extracted from various parts of the body. They have been extracted from bone marrow and adipose tissue for a few decades. More recently, birth tissues from live births, including umbilical cord blood, cord tissue, with Wharton’s Jelly, and amniotic membrane tissue, have been found to be a rich source of both HSCs and MSCs and in addition, precipitate target tissue production of MSCs through paracrine signaling. Growth Factors, Cytokins, Exosomes & micro-RNA from birth tissues give rise to Stem cells in this way. These cells, as well as MSCs contained in Wharton’s Jelly tend to be more fit than stem cells obtained from adult stem cells.

 

WHARTON’S JELLY

 

Wharton’s jelly is a gelatinous substance found in the umbilical cord which is rich in stem cells. Studies have shown that mesenchymal stem cells (MSCs) have low immunogenicity. Human umbilical cord Wharton’s jelly provides a new source for MSCs that are highly proliferative and have multi-differentiation potential. Wharton’s Jelly Cells (WJCs) express MSC markers but low levels of human leukocyte antigen (HLA)-ABC and no HLA-DR.  WJCs have low functional  immunogenicity and therefore recipient rejection has not been documented.

 

Advanced Regenerative Medicine

Advanced Regenerative Medicine involves the use of regenerative biomolecules, tissue engineering and stem cells to treat diseased or injured tissues.

We want to talk here about the fascination that stem cells produce over scientists and lay people. Ever since we heard about this microscopic buddies for the first time, we started imagining endless possibilities for treatments and, why not: cures.

So scientists went right to work. One of the objectives was to find ways to control how stems cells develop into other cell types, in the hopes of creating new therapies. The work is on its infancy but,  as we all hear constantly, it is very promising.

Researchers have learned that pluripotent cells—stem cells that have the ability to differentiate into any kind of cell- when cultured in certain types of confined spaces started activating genes that determined the tissue those cells were going to become.  Most of the medical investigation on stem cells has focused on modifying the combination of growth solutions to stimulate differentiation. The cellular surroundings are an important element to controlling how stem cells transform into other cell types. The research continues. and the perspectives are exciting. We have already obtained dopamine producing neurons from pluripotent cells! We have already created a sugar based scaffold of blood vessels!!

Now what happens out of the lab?. Physicians and patients alike have embraced the use of fresh adult stem cells obtained from fat or bone marrow to treat some degenerative conditions. Clinical trials have demonstrated significant improvement, for example in knee osteoarthritis, sports injuries, frozen shoulder etc. What happens in this case? how do these cells work?. Well: adult stem cells not necessarily differentiate or “become” cartilage, or tendon, or muscle. By the release of information, proteins, anti-inflamatory elements; this cells will influence the environment and stimulate the growth and differentiation of the local cells, hence regenerating and healing damaged tissue. So with slight differences what is being achieved in the laboratory, happens in a very natural fashion inside our bodies through the harnessing of our own cells healing power!

Isn’t it all short of amazing?

 

Will see you in the next blog. Keep your cells healthy!

So we have been in the regenerative medicine specialty for about 8 years. Just like pretty much everyone, we started by using Platelet Rich Plasma. We learnt about it, we were fascinated by it and we treated our patients with it. Patients loved and so did we. ‘

PRP, if obtained and used correctly is a very powerful tool to implement in any medical practice. Especially if we deal with the elderly, osteoarthritis, wear and tear of tendons and ligaments, loss of vitality. The PRP is also very frequently used in Plastic and reconstructive surgery. For wound care, scar improvement and overall rejuvenation of the skin.

But why does it work? and how?

Well, we are all familiar with platelets. They seem to have significant power and influence over tissue regeneration, and by concentrating them in a blood sample we can obtain signaling proteins, cytokines and growth factors. If we add white blood cells to the mix, we will have what is called L-PRP (leukocyte rich PRP), which makes that “soup” even more interesting.

Now, to harness the power of those bioactive substances we need to coax the cells into releasing them. Normally the platelets get activated by the addition of calcium, or by contact with collagen. But several studies have demonstrated the influence of laser of low intensity over the activity of some cells. That effect is called “Photobiomodulation”. Basically  it is form of light this modality uses non-ionizing light sources, like LEDs or Helium-Neon lasers to produce photochemical events at various biological scales. It have been demonstrated that this light will react with the enzyme Cytochrome C oxidase which is paramount in the mitocondrial processes.

Several scientists went on to study this light and its effects over cellular cultures. and they found that cells proliferate more when exposed to low level laser, they also showed increased viability!

So we went on to compare the levels of cytokines and growth factors in an irradiated sample and a non irradiated one. And sure enough some of the growth factors even tripled the concentrations after laser exposure. The famous Interleukin 10, anti inflammatory protein doubled the levels, endorfines were released in high levels.

It has been established that the photobiomodulation process will give extraordinary benefits in pain management or inflammation, immunomodulation, and promotion of wound healing and tissue regeneration, and it plays a  fundamental part in our protocols.

 

Isn’t it all short of amazing?

 

Will see you in the next blog. Keep your cells healthy!

Hair loss is very common, with tens of millions, if not hundreds of millions of people all over the world suffering from it. Hundreds of thousands of people decide to utilize hair restoration therapy, as well as other procedures in order to try to get at least some of their former hair back. Although some are effective, most of the time, the treatments only move already existing hair from one place to another. However, with Stem Cell therapy, we try to help new hair grow by helping the follicles to regenerate.

 

Adimarket helps, alongside a few other companies, to help provide new and reliable uses for PRP and stem cell therapies. We provide the equipment and other services so that doctors and practices will be able to provide these services to their patients.

 

There’s a Lot of Promise

 

While the main people talking about PRP and stem cell therapies are smaller companies like us, many other people are also discussing and seeing potential in these therapies. These include doctors, and practices, such as a doctor from Miami known as Lazaro M Garcia Md. This doctor already utilized PRP and stem cell therapy for people who suffer from hair loss, and is currently conducting a study that is supported by the National Institutes of Health.

 

In order to participate in the study, patients pay a small fee, which changes based on what part of the study they are in. Afterwards, the receive 2 injections of PRP and stem cells that are made from their own body, over 3 months.

 

Dr. Garcia is utilizing the body’s own growth factors in order to increase the amount of blood and nutrients to the otherwise dead hair follicles. This makes the dead follicles more lively and allows them to create new hair growth.

 

The way to make Platelet Rich Plasma is to is to use the patients own blood, which can come from either bone marrow, or other sources of fat. They go into a centrifuge, which concentrates the composition, and then allows them to be injected into the treatment site. While it is an otherwise simple procedure, some training in still necessary to ensure that it is done safely.

 

We Provide Equipment

 

We at Adimarket do not perform stem cell and PRP therapies, but we do offer the equipment so that doctors and practices can do so themselves. These include amniotic tissue, stem cell and PRP kits, centrifuge devices, and many more. Practices and doctors can order directly from us.

 

It is good to note that not all PRP systems are equal. The system that we have uses the closed tabletop system that is able to process the PRP in under 10 minutes. For more information, contact us or visit our website.

 

Hair loss is a serious problem with many people suffering from it. Now, thanks for PRP and stem cell therapies, we no longer only have to rely on hair replacement surgery to help patients. PRP and stem cell therapies may be the best therapy out there for both your patients, as well as your practice.

Here at Adimarket, we sell equipment to practices that are willing and able to add PRP and stem cell therapies to their lineup. The equipment we offer is among the best, and we have helped hundreds of doctors and practices to offer PRP and stem cell therapies. However, we also provide marketing services above that as well.

 

Although it might see odd that we offer both marketing services, as well as equipment, but it is not so odd once you understand why. Simply offering services and having the equipment to do so does not in itself help patients to fully know that you are offering new services. It is best practice to get the word out to as many people in the area as possible.

 

While there are many reasons why we do this, here are the three main reasons why.

 

Regenerative Medicine Was Founded Not Too Long Ago 

Compared to many other medical practices, such as surgery and physical therapy, regenerative medicine is still fairly new. In fact, most people do not really know that PRP and stem cell therapy even exists, let alone can be used to manage chronic pain.

 

The fact that not many people even know about the existence of regenerative medicine, let alone what it can be used for, means that it would be difficult to get your patients to even understand what you are offering as a service. This can be addressed with marketing. Through marketing, a practice can not only let it become known that they are offering these new services, but also explain shortly what the service entails.

 

Marketing Is Like Dieting 

Pretty much every doctor and dietitian knows that good nutrition is vital to great health down the line. Waiting until you’re sick and deficient to discuss nutrition is not the best way to address the issue. Marketing is similar in that instance. Marketing not only can be used to keep current patients informed, but can also be used to inform new patients about what you offer. Practices that don’t market often suffer in the same way as people who don’t get good nutrition.

 

There’s a lot of competition 

Medicine has sadly become more and more like a business in the past years. This means that even doctors and practices need to have a good business sense if they are going to continue to be able to provide the type of services that patients need and desire. Not understanding business would only make any practice fail or at least prevent them from growing.

 

Because of this, private practices, as well as other medical groups are forced to compete. Marketing is a big way to make sure that you get patients instead of your competition. If you are utilizing PRP and stem cell therapies as a way to generate more income, then great! However, you will still have to market those services to get the word out, as well as compete.

 

We at Adimarket offer these services as a way to help the field of regenerative marketing succeed. We not only help your practice start to utilize regenerative medicine, but we also help you to promote your practice in the same way. This will help your patients know that you are using these methods, and what they are, so that you can get a leg up over the competition.

Stem cell therapy’s future

Stem cells from adults were found to save the lives of leukemia patients through bone marrow transplants more than 30 years ago. Since these stem cells were able to help treat leukemia and lymphoma, many scientists tested to see if this treatment can have other beneficial uses as well, such as treating other diseases and injuries. In the 80’s and 90’s, this started the Stem Cell debate, and although that has become much calmer of a debate, we are still waiting to see the boom of medical advancements promised by stem cell researchers.

 

While researchers may have over-exaggerated the exact benefits that stem cell therapy may have had, we at Adimarket knows that there are many more benefits of stem cells than we currently know. We just need to give it a little more time for researchers to understand the knicks and knacks of how stem cells interact with the human body.

 

What Are The Different Types of Stem Cells

The first while after stem cell research began, most of the time was spent learning about the two types of stem cells. These types are Adult, and Embryonic. Adult stem cells are used for bone marrow transplants and a few other treatments. Embryonic stem cells have proved to be too impractical to be useful.

 

A few decades later, in 2006, researchers in japan found a new way of using adult stem cells. They learned how to basically reprogram adult stem cells to act more like embryonic stem cells, and can become whatever cell type is needed at the time. These new cells were called Pluripotent, or iPS, stem cells.

 

While these cells were, in practice, viable, they did not come without complications. For instance, the new iPS cells became prone to mutation over time, leading to cancer in some instances.

 

Making The Research More Targeted

While the problems became a setback for some, it actually helped us to understand stem cells in the long term. Today, the focus of stem cell research is more about targeted therapies mainly used to help tissue damage, and this make sense.

 

Since cell reprogramming is no longer used as a method, stem cells taken from a tissue can only be used to create that same tissue. For instance, stem cells taken from a joint can only be used to make the tissue that the stem cells came from. This limits what stem cells can currently do at the present time. However, we believe that these limits are not permanent, and researchers will eventually find new and exciting ways to utilize stem cells.

 

Until then, Adimarket is happy to provide the equipment necessary to allow practices to utilize Platelet Rich Plasma and Stem Cell therapies. We hope that our equipment can be used to offer more treatment options for patients who are suffering from injuries and arthritis.

 

PRP and stem cell therapies seem to have a pretty bright future ahead of them. If you are a doctor or own a practice, you can be a part of this future by purchasing our equipment. If you have any questions for us, or want to know more, you can visit our website.

Hair loss is very common, with tens of millions, if not hundreds of millions of people all over the world suffering from it. Hundreds of thousands of people decide to utilize hair restoration therapy, as well as other procedures in order to try to get at least some of their former hair back. Although some are effective, most of the time, the treatments only move already existing hair from one place to another. However, with Stem Cell therapy, we try to help new hair grow by helping the follicles to regenerate.

 

Adimarket helps, alongside a few other companies, to help provide new and reliable uses for PRP and stem cell therapies. We provide the equipment and other services so that doctors and practices will be able to provide these services to their patients.

 

There’s a Lot of Promise

While the main people talking about PRP and stem cell therapies are smaller companies like us, many other people are also discussing and seeing potential in these therapies. These include doctors, and practices, such as a doctor from Miami known as Lazaro M Garcia Md. This doctor already utilized PRP and stem cell therapy for people who suffer from hair loss, and is currently conducting a study that is supported by the National Institutes of Health.

 

In order to participate in the study, patients pay a small fee, which changes based on what part of the study they are in. Afterwards, the receive 2 injections of PRP and stem cells that are made from their own body, over 3 months.

 

Dr. Garcia is utilizing the body’s own growth factors in order to increase the amount of blood and nutrients to the otherwise dead hair follicles. This makes the dead follicles more lively and allows them to create new hair growth.

 

The way to make Platelet Rich Plasma is to is to use the patients own blood, which can come from either bone marrow, or other sources of fat. They go into a centrifuge, which concentrates the composition, and then allows them to be injected into the treatment site. While it is an otherwise simple procedure, some training in still necessary to ensure that it is done safely.

 

We Provide Equipment

We at Adimarket do not perform stem cell and PRP therapies, but we do offer the equipment so that doctors and practices can do so themselves. These include amniotic tissue, stem cell and PRP kits, centrifuge devices, and many more. Practices and doctors can order directly from us.

 

It is good to note that not all PRP systems are equal. The system that we have uses the closed tabletop system that is able to process the PRP in under 10 minutes. For more information, contact us or visit our website.

 

Hair loss is a serious problem with many people suffering from it. Now, thanks for PRP and stem cell therapies, we no longer only have to rely on hair replacement surgery to help patients. PRP and stem cell therapies may be the best therapy out there for both your patients, as well as your practice.

Platelet Rich Plasma is a very important material, as it is be vital in treating bone and joint deterioration. Many patients have tried using PRP therapy as a treatment as an alternative to surgery and other procedures that can be invasive. This therapy relies on extracting platelets and other cell types, such as growth factors, from the patients blood, and concentrating them.

 

Many conditions have been treated by using this therapy, such as knees, hips, spines, shoulders, and pretty much any part of your body that has a joint or connective tissue.

 

What The Procedure Is Like 

The procedure involves an injection of PRP at the point where treatment point. During the day, when the patient comes in, they wait while the PRP is processed. When it is done, the skin of the treatment site will be cleaned and sanitized much like a normal injection, such as a flu shot. Then, using ultrasound or fluoroscopy, the needed will be guided to the treatment area.

 

It generally takes less than 15 minutes for this procedure to take place. Then the physician or doctor in question will provide the patient with a list of things they should or should not do, such as not taking NSAIDs, such as Advil or Tylenol. If needed, other non-NSAID pain relievers may be prescribed.

 

What Should You Expect? 

PRP brings platelets and growth factors in a concentrated form to the treatment area, as a result, your body reacts in a way that ultimately increases tissue repair. This bodily process will occur for weeks, even after one application of PRP.

 

After about a month to 6 weeks, most patterns will start to feel their pain decrease, and their mobility get better. This can occur for up to half a year. While most patients are satisfied with just one treatment, many will have more than one, depending on the severity of the defect. As a result of how well this treatment works many patients are able to avoid surgery altogether with just a couple of shots.

PRP and Stem Cell Therapy still has a ways to go before it becomes mainstream medical practice. However, we at Adimarket are proud to be a part of this growing trend. We fervently believe in the future of stem cell therapies because we trust that this is an alternative to otherwise invasive and unneeded medical procedures.

 

If we listed every single scientific reason showing the benefits of stem cell therapy, we would be writing a book. In order to help keep this short, we have decided to instead make it into 3 reasons for why we side with this therapy and sell equipment for such.

 

1. It’s Been Around For Awhile

Stem cell therapy is not a new invention, nor is it an untested invention. This has been a therapy that has been going on for decades, and have been used for many procedures, such as bone marrow transplants for leukemia patients. The main issue is that stem cell therapy is just not that widely known.

 

This has been benefiting people who have suffered from leukemia, and well as other diseases like lymphoma for decades. The most common usage arising from bone marrow transplants. This is because they can be used safely and have pretty much no risk of rejection due to them being the bodies own cells. If they can be used to treat thee conditions, there is probably much more that they can be used for as well.

 

2. It’s Not Really Invasive

Invasive procedures will probably never  fully be obsolete, a good case of this would be a bone fracture, or a having to get a tooth pulled. There is nothing that can be done outside of an invasive procedure for these types of injuries. However, not all cases of invasive surgery are necessary.

 

This is why we at Adimarket love them cell therapy so much, because it is minimally invasive. Instead of needing an incision and stitches, the most that a patient will need is a needle poke to extract stem cells, and another to put them in the treatment area. This helps to not only reduce the risk of infection, but also helps prevent other complications as well, such as scarring.

 

3. It Works to Improve Healing

The last reason for us promoting stem cell therapy, is because it allows the body to heal naturally. This means that the treatment actually addresses the underlying problem, instead of just focusing on symptom management.

 

We hope that this helps patients to get better and more effective treatment, and can treat the whole issue, instead of just the symptoms of the issue. While stem cell therapy might not be the best choice for every case, it is no different than any other medical procedure. Not all treatments require medication and surgery, for instance.

 

If you are seeking out better and more efficient ways of treating injuries and various diseases, Adimarket is the place to go. We provide the latest and greatest technology and equipment in relation to PRP and stem cell therapy. These will help you to find better treatment for your patients.

 

Stem cell therapy can be highly beneficial when it comes to not only treating patients, but also to increase your revenue. Incorporating stem cell therapy may very well be the best thing that you can do for your practice.

PRP and Stem Cell Therapy still has a ways to go before it becomes mainstream medical practice. However, we at Adimarket are proud to be a part of this growing trend. We fervently believe in the future of stem cell therapies because we trust that this is an alternative to otherwise invasive and unneeded medical procedures.

If we listed every single scientific reason showing the benefits of stem cell therapy, we would be writing a book. In order to help keep this short, we have decided to instead make it into 3 reasons for why we side with this therapy and sell equipment for such.

  1. It’s Been Around For Awhile

Stem cell therapy is not a new invention, nor is it an untested invention. This has been a therapy that has been going on for decades, and have been used for many procedures, such as bone marrow transplants for leukemia patients. The main issue is that stem cell therapy is just not that widely known.

 

This has been benefiting people who have suffered from leukemia, and well as other diseases like lymphoma for decades. The most common usage arising from bone marrow transplants. This is because they can be used safely and have pretty much no risk of rejection due to them being the bodies own cells. If they can be used to treat thee conditions, there is probably much more that they can be used for as well.

 

  1. It’s Not Really Invasive

 

Invasive procedures will probably never  fully be obsolete, a good case of this would be a bone fracture, or a having to get a tooth pulled. There is nothing that can be done outside of an invasive procedure for these types of injuries. However, not all cases of invasive surgery are necessary.

 

This is why we at Adimarket love them cell therapy so much, because it is minimally invasive. Instead of needing an incision and stitches, the most that a patient will need is a needle poke to extract stem cells, and another to put them in the treatment area. This helps to not only reduce the risk of infection, but also helps prevent other complications as well, such as scarring.

 

  1. It Works to Improve Healing

 

The last reason for us promoting stem cell therapy, is because it allows the body to heal naturally. This means that the treatment actually addresses the underlying problem, instead of just focusing on symptom management.

 

We hope that this helps patients to get better and more effective treatment, and can treat the whole issue, instead of just the symptoms of the issue. While stem cell therapy might not be the best choice for every case, it is no different than any other medical procedure. Not all treatments require medication and surgery, for instance.

 

If you are seeking out better and more efficient ways of treating injuries and various diseases, Adimarket is the place to go. We provide the latest and greatest technology and equipment in relation to PRP and stem cell therapy. These will help you to find better treatment for your patients.

 

Stem cell therapy can be highly beneficial when it comes to not only treating patients, but also to increase your revenue. Incorporating stem cell therapy may very well be the best thing that you can do for your practice.