Can Stem Cells treatment Regrow the knee cartilage?
Some people believe that stem cell does all of this but studies have shown that It’s unlikely only in a few unique cases. You can observe minimal growth a year after the patient took treatment, but this doesn’t mean replacement of the cartilage.
The cartilage has a reduced regenerative capacity, and current and present pharmacological medications only offer symptomatic pain relief. Osteoarthritis patients that respond poorly to conventional therapies are ultimately treated with surgical procedures to promote cartilage repair by implantation of artificial joint structures (arthroplasty) or total joint replacement (TJR). Surgery has been the last resort for serious cartilage problems.
In the last two decades, stem cells derived from various tissues with varying differentiation and tissue regeneration potential have been used for the treatment of osteoarthritis, damage to bones and others either alone or in combination with natural or synthetic scaffolds. The stem cells derived from these tissues primarily aid cartilage repair. Although stem cells can be differentiated into chondrocytes in vitro or aid cartilage regeneration in vivo, their potential for Osteoarthritis management remains limited as cartilage regenerated by stem cells fails to fully recapitulate the structural and biomechanical properties of the native tissue. It isn’t easy for the cartilage to regrow and assume its original biomechanical and structure form.
Apparently, Due to the limited intrinsic capacity of resident chondrocytes to regrow the lost cartilage post-injury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair.
Also, stem cell-based therapies using mesenchyme stem cells (MSCs) or induced pluripotent stem cells (iPSCs) have been used successfully in clinical and preclinical situations.
Part of the issues associated with Mesenchyme stem cells can be averted by using iPSCs. iPSCs are an ideal patient-specific unlimited cell source for autologous tissue regeneration. With the Promising in vitro; studies have shown that vitro results have already been demonstrated in the cartilage engineering field for iPSCs. These were generated from various cell types.
What Is Cartilage and How Does It Get Damaged?
Cartilage is a connective tissue in the human body and body of other animals. In our joints, we have a few kinds of cartilage, but most often people refer to the smooth lining of a joint called articular or hyaline cartilage. This kind of cartilage gives rise to a soft layer of cushion on the end of a bone at the joint. The cushion is essential for balance, mechanical functions and athletics. This tissue of the cartilage is very strong, yet it can compress, readjust and absorb varying degrees of energy. It is also very slippery, smooth and flexible and these features allow the joint to glide effortlessly through a broad range of physical motions of any kind.
When joint cartilage is not working correctly or damaged, this smooth-cushioning-layer can be worn away, and this becomes a problem. In the case of traumatic injuries, sometimes a sudden force causes the cartilage to break off or poorly become damaged, exposing the underlying bone of the body. In the case of osteoarthritis (also called degenerative/wear-and-tear arthritis), over time that smooth layer can wear thin and uneven. Aging can also cause the cartilage to break off and certain life factors and diseases too, e.g. autoimmune diseases.
Eventually, as that cushion of the bones wears away, joint movements can become inflexible, stiff and painful on one or both legs (bones). Joints can even become inflamed and swollen. And as all these conditions, typically causes pain and limitations in activity become problematic. The action or activities that involve these bones leads to crushing pain and discomfort, depending on the severity of the case. Almost all activities involve the movement of bones; hence this condition is not an easy one.
There are some treatments for cartilage damage and arthritis. Although there some medicines, most of these treatments are focused either on relieving symptoms by smoothing down the damaged cartilage or concentrate on replacing the joint surface with an artificial implant. The later is for end-stage conditions, and the artificial plane is procedures such as knee replacement or hip replacement surgery.
How Can Stem Cells Help?
Stem cells are specialized cells that can multiply reform and develop into different types of tissue. In the developmental stages of a fetus, stem cells are plentiful and surplus. However, in adulthood, stem cells are restricted to specific tasks of regenerating a few types of cells, such as blood cells and liver cells in some cases of damage. There are almost no stem cells found in cartilage tissue, and therefore there is little to no capacity to heal or regrow new cartilage. For adults, the ability to regrow new cartilage is even more difficult due to age and lack of stem cells in the cartilages.
Most often, in the setting of orthopedic surgery and joint problems, stem cells are obtained from adult stem cell sources. The primary sources are bone marrow and fatty tissue. These stem cells can develop into cartilage cells, called chondrocytes.
They also exhibit some other helpful qualities by stimulating the body to reduce inflammation, stimulate cell repair, and improve blood flow. This process is caused by the secretion of cellular signals and growth factors to stimulate the body to initiate healing processes.
Once stem cells have been obtained, they need to be delivered to the area of the cartilage that damaged. One option is to inject the stem cells into the joint. There have been many studies investigating just this, and some data shows improvement in symptoms. How much of this improvement is the result of new cartilage growth versus other effects of stem cells (the healing properties listed above, including the anti-inflammatory effects) is unknown.
There is a challenge with giving stem cell injection. The problem with just injecting stem cells is that cartilage is a complex tissue that is comprised of more than only cells hence this can pose a challenge because the stem can’t regenerate all the things in the cartilage.
To regrow the cartilage, the complex tissue structure and biomechanics of cartilage must also be reconstructed to its former status. Cartilage can often /described as having a scaffold-like structure that is composed of water, cells, collagen, and proteoglycans, and infection-fighting antibodies. Injecting just the stem cells is thought to be less effective in stimulating the formation of the entire cartilage structure hence the challenge.
Some studies are investigating the types of 3-dimensional tissue scaffolds engineered to have a cartilage-like structure. The stem can then be injected into the scaffold, in hopes of better restoring a healthy type of cartilage. Three-dimensional printing is becoming an exciting part of this type of research. If everything works out as expected, the cartilage reconstruction could be achieved to a very high percentage.
How do stem cells work?
Necessarily, stem cells are progenitor cells which are capable of regeneration and differentiation into a wide range of specialized cell types. Once injected, stem cells follow inflammatory signals from damaged tissues and have multiple ways of repairing these damaged areas. It works as though the part is developing new; like what is seen during a child’s development.
The mesenchyme stem cells (MSCs) we are using are considered to be multipotent (they can transform into different cell types but cannot form an organ) but not pluripotent. In the body, these cells Do NOT function by transforming into different cell types or tissues.
They act via anti-inflammatory activity, immune modulating capacity, and the ability to stimulate regeneration. We go through a very high thorough screening process to find cells that we know have the best anti-inflammatory activity, the best immune modulating capacity, and the best ability to stimulate regeneration process on the tissue with damage.
ISSCA (International Society for Stem Cells Applications) www.issca.us
This is a business located in Miami, FL, where people around the world come to take a certification in the newest Stem Cells Protocols.
Some organizations have put in efforts to help discover some solutions in stem medicine. International Society for Stem Cell Application (ISSCA ) is one of the leading associations in setting standards and promoting excellence in the field of Regenerative Medicine, researches, publications related education, certification, research and publications.
The ISSCA is a unique-multidisciplinary community of physicians, stem specialist and scientists with a mission to advance the science, technology and practice of Regenerative Medicine. Their aim is to treat disease and lessen human suffering. ISSCA generally advances the specialty of Regenerative Medicine and serves its members.
The ISSCA provides certifications and standards in the practice of Regenerative Medicine as a medical specialty.
Although the expectation on this stem cell course is yet to be achieved; however, this is a part of medicine that can offer one-end-solution to various bone and body problems.
With the recent high-tech studies, efforts and dynamics, stem cell treatment can be a breakthrough in the future as its perspectives are very promising and unique. It is also not dangerous on the long-run.
- Published in Corporate News / Blog
Why Dermatologists Should Use Platelet-Rich Plasma (PRP)
PRP is a powerful means of regenerating tissues, and has pretty a pretty large growth in popularity among patients, especially those who suffer from alopecia. This is despite the apparently lack of evidence that supposedly surrounds the treatment.
Is It A Lack Of Evidence Or Just A Lack Of Funding?The lack of widespread research may have more to do with funding than anything else. Many of the studies that are currently out there about PRP were unfunded, especially on the subject of Hair Regeneration. However, despite this lack of funding, the demand for PRP treatments for hair loss is growing at an unprecedented rate.
When it comes to PRP kits, there are three kinds to choose from. Ones that use gels, one that create a buffy coat, and one that creates a buffy coat utilizing a double spin. It is pretty unanimous that the last option creates the most reliable and concentrated form of PRP possible, at 5-7 times the baseline amount of platelets.
This concentration level also has the most nutrients which helps for the regeneration of blood vessels and stem cells. One commonly recommended tactic is to combine PRP hair regeneration with micro-needling with a topical layer of PRP. This may be beneficial in some cases.
Micro-needling is a way to create small amounts of trauma, which the body reacts to via a healing response. This response, mixed with PRP, can help to stimulate the growth of new cells.
In some instances, a dermatologist might have three sessions, with the first two being PRP injections, and the middle one being a micro-needling with a PRP topical solution. However, micro-needling is completely optional. Whether you choose to use this method or not, you will still be injecting the patient with PRP at the scalp.
Combining PRP with an Allograft Matrix
One thing that many hair regeneration experts do is combine PRP with an Allograft matrix. These are often used when healing wounds, as it changes inactive adult stem cells back into an active form. This makes the wounds heal faster.
This is because an allograft acts like a scaffold that proliferates cell regrowth and speeds up the healing process. Many experts in the fields have noted a high degree of success by using this method.
Allografts are generally made from using the bladder tissue of pigs. However, a better type of allograft is made from amniotic tissues and fluid. This type of allograft can be utilized with little or no chance of being rejected by the body, as opposed to those made from pig bladders.
Medications Vs PRP
The main drugs that are commonly used to regrow hair are Minoxidil and Finasteride. These were designed to be able to prevent male pattern hair loss, but did almost nothing when it came to regrowing lost hair. However, these drugs have been well known to only be temporary solutions, and if the patients stopped taking the drugs, the benefits of them would quickly reverse. These are also not 100% effective at stopping hair loss either, but it can slow the progression.
However, PRP is different. It may actually be the only treatment on the market that has been clinically proven to regrow hair and heal hair follicles. This means that it only only slows down hair loss, but actually helps with hair growth.
Many may ask how temporary the solution is, saying that the other drugs on the market are just temporary solutions. However, many pateints report that a PRP and allograft combination treatment was able to give them great results that lasted for nearly half a decade or more with just one treatment. However, each patient is indeed different.
Aside from drugs, we only had one other choice when it came to hair loss, and that was hair transplants. This is why PRP has been growing in popularity in hair regrowth groups lately. Although those other treatments are not obsolete in the slightest, adding PRP therapy can be both beneficial and safe to patients in the long run.
Some people combine the two, and use PRP alongside Minoxidil and Finasteride with little to no side effects seen to date. You can even combine PRP with laser light scalp stimulation therapy, but that is up to you.
So Try It Out
PRP for hair regeneration, skin rejuvination, and even facelifts is going strong with no sign of stopping. Many dermatologists have already taken the plunge, and since this treatment is not going anywhere anytime soon, it may behoove you to join in on it too.
For more information about PRP including equipment, check out the Adimarket website. We provide great tools for any practice to utilize.
- Published in Corporate News / Blog