To understand why stem cell platelet-rich plasma or co-transplantation of Adipose-derived mesenchymal stem cells and PRP, is such a remarkable idea in regenerative medicine, let’s spend a little time looking at the mechanics of PRP.

Platelet-Rich Plasma’s Role As Repairmen

The one thing that makes Platelet-Rich Plasma a hero in several fields (if not all) of medicine is the fact that the diverse growth factors in it are able to stimulate stem cell proliferation and cell differentiation (the factors that determine effective tissue regeneration and healing) on any part of the body.

These growth factors are abundant in the blood and act as the natural repairmen of tissues.

In the perfect scenario, there’s plenty of blood flow to every part of the body and these “repairmen” are always on-call to address any healing needs that may arise. However, if the injured area has a poor blood supply — especially areas that are constantly move like tendons, ligaments and joints — demand for these repairmen can outgrow supply. Meaning, healing (or regeneration of tissues) is put on hold till further repairmen are available.

The train of Platelet-Rich Plasma then arrives with enough of these repairmen to warrant resumption of healing.

There’s another part of this picture we haven’t talked about so far: stem cells.

As far as Platelet-Rich Plasma and it’s growth factors are concerned, they are mere repairmen. They can’t do the work by themselves. They need the basic raw materials to work with. And that raw material here is the stem cells.

Stem cells are the ones actually being regenerated to form new tissues for healing.

Stem Cells As The Raw Materials For PRP

Stem cells are the only raw materials that PRP works with for regeneration. These are like the fundamental building blocks of all other cells. These cells can be can be guided into becoming specialized cells under the right conditions.

In addition, they can also divide themselves to form new stem cells or new specialized cells.

So for Platelet-Rich Plasma to work well, it needs to be applied to an area with lots of stem cells like the heart, liver, blood vessels etc. Incidentally Platelet-Rich Plasma’s healing properties were first discovered by cardiac surgeons who played with concentrated blood for faster healing of heart after surgery and it showed tremendous promise because stem cells are abundant in heart tissues.

But what if healing is needed in an area where there are not much stem cells?

With the new developments in stem cell technology that can be solved too. Because now we can supply the stem cells to areas where there are less like the joints, ligaments and tendons. For this, scientists usually use “mesenchymal stem cell” or MSCs. These are cells isolated from stroma and can differentiate to form adipocytes, cartilage, bone, tendons, muscle, and skin.

The most easiest way is to harvest it from adipose tissue or fat that we call Adipose-derived mesenchymal stem cells or ADSC.

Stem Cell Platelet-Rich Plasma

Supplying Both PRP And Stem Cells For Regeneration

In regions with hypoxia (poor blood supply) like joints, meniscus tissue, rotator cuff, spinal discs etc the supply of platelets (and therefore growth factors) as well as the stem cells are limited. So what if we supplied both the stem cells and Platelet-Rich Plasma for triggering the regeneration process?

That’s the question these Japanese scientists answered in their research. Here’s another group of scientists who took on the same challenge.

They used Adipose-derived mesenchymal stem cells (ADSC) which is known for their ease of isolation and extensive differentiation potential. These researchers noted that these stem cells often can’t survive in areas of local hypoxia, oxidative stress and inflammation – thereby making them ineffective. However, when Platelet-Rich Plasma (or thrombin-activated PRP) is added to ADSC, it kept them alive for prolonged periods and the growth factors in the Platelet-Rich Plasma triggered cell differentiation and proliferation more easily.

Why This Exact Combination Is The Future

Done this way, both Adipose-derived mesenchymal stem cells (ADSC) and Platelet-Rich Plasma are raw materials for healing that’s already available in plenty in almost every one (there are exceptions of course). That means, for complete healing to take place this combination treatment, still in it’s very primitive stage of development, may have the potential to replace expensive synthetic drugs that carry complex unexplained side effects. The procedure takes our body’s natural healing agents — stem cells from body fat and PRP from blood — and then inject it inside knee or other joints (or other areas where they are insufficient) for regeneration.

Isn’t that like the most wonderful thing ever?

Whether it’s cartilage cell, or a bone cell, or a collagen cell for ligaments and tendons that needs to be healed, all you need is a same-day procedure by a local, but specialized doctor, using the natural ingredients of the body.

I believe this special combo is a huge win for Platelet-Rich Plasma.

The Challenges For Growing Adoption Of This Treatment

We know Platelet-Rich Plasma has safe, yet high-speed recovery potential with it’s multiple growth factors. And it is effective in regenerative healing of cartilage injuries – the most toughest injuries to heal – as well as Osteoarthritis. However the challenges are Platelet Quality. We need to somehow ensure the Platelet-Rich Plasma quality is uniform. Currently it varies from two to several fold above baseline concentration based on donor’s physical condition.

Next we need to identify the exact PRP growth factors that promote ADSC proliferation. Scientists believe growth factors such as basic fibroblast growth factor (bFGF), epidermal growth factor, and platelet-derived growth factor stimulate stem cell proliferation while some growth factors under certain conditions are known to inhibit the process.

The percentage of PRP matters too. 5 percent, 10 percent, 15 percent and 20 percent Platelet-Rich Plasma in ADSC are tested by scientists.

The Only Treatment In Modern Medicine For Cartilage Regeneration

The bottom line is that Stem Cell Platelet-Rich Plasma or ADSC + PRP procedure is the only treatment in modern medicine that has showed cartilage regeneration. So it’s too important to ignore. And it could one of greatest advances that science has brought to the millions of people suffering from serious pain in their joints, knee and spine as well people suffering from all kinds of tendon diseases and injuries.

 

Biotrend alliance

Global Stem Cells Group announces plans to sign a strategic alliance with BioTrend Turkey, an innovative biotechnology company focused on genetic, biochemistry, molecular biology, biomaterials and stem cell technologies.

MIAMI, Nov. 20, 2017— Global Stem Cells Group (GSCG), a world leader in stem cell and regenerative medicine, announced plans to sign a strategic alliance with international biotechnology company BioTrend, which services the Turkish health sector.

GSCG’s goals for the alliance are three-fold:

  • Organize Turkey’s first International Society for Stem Cell Application (ISSCA) regenerative medicine symposium in April 2018, in Istanbul.
  • Host two hands-on regenerative medicine certification training courses per year in Turkey.
  • BioTrend will promote and distribute Adimarket regenerative medicine equipment and supplies in the region.

The two-day, hands-on training courses were developed for physicians and high-level practitioners to learn techniques in harvesting and reintegrating stem cells derived from adipose tissue and bone marrow. Coursework will focus on stem cell technologies and regenerative medicine protocols. Participating physicians learn skills that can be used to treat patients in their practices, and for career advancement.

“This new alliance with BioTrend is a great opportunity to advance the benefits of stem cell medicine in Turkey,” says Global Stem Cells Group CEO Benito Novas.  “Turkey’s geographic location bridges Europe and Asia, allowing GSCG to have a widespread influence in establishing our regenerative medicine presence in both Europe and Asia.

“We are excited to work with BioTrend’s innovative team, and move one step closer to establishing Global Stem Cells Group as the leader in regenerative medicine therapies worldwide.”

The alliance is part of Global Stem Cells Group’s push to highlight Turkey’s appeal as a destination for patients seeking stem cell therapies for a variety of conditions.

Stem cell therapies continue to revolutionize the anti-aging aesthetics industry and help improve the quality of life for patients suffering from some chronic conditions.

To learn more about the Global Stem Cells Group Symposium in Istanbul, visit the stemcellconference.org website, email info@stemcellsgroup.com, or call 305-560-5337.

About Global Stem Cells Group:

Global Stem Cells Group (GSCG) Global Stem Cells Group (GSCG) is a worldwide network that combines seven major medical corporations, each focused on furthering scientific and technological advancements to lead cutting-edge stem cell development, treatments, and training. The united efforts of GSCG’s affiliate companies provide medical practitioners with a one-stop hub for stem cell solutions that adhere to the highest medical standards.

Global stem cell’s mission is to be the largest recognized stem cell and regenerative medicine network in the world.

About AdiMarket:

Biotrend Alliance

Adimarket, Inc., a division of the Global Stem Cells Group, is a one-stop, cost-competitive online marketplace for quality regenerative medicine equipment and supplies for physicians and health care professionals.

Adimarket was founded to provide practitioners the tools they need to practice regenerative medicine in a medical office setting. Motivated by a firm belief in the impact stem cell medicine can have when dispensed in a doctor’s office, Adimarket provides physicians with the tools they need to provide patients with cutting-edge treatments.

About BioTrend:

BioTrend AllianceBioTrend was established in Cleveland, Ohio, in 2004, and has been serving the Turkish health sector since 2005. As part of the textile and construction company group, BioTrend benefits from the group`s 25 years of international business experience to move forward stronger and more professionally.
BioTrend focuses on genetic, biochemistry, molecular biology, biomaterials and stem cell technologies; the company has introduced a significant number of innovative technologies to the Turkish healthcare industry. The technologies and products which are safe, high technology and proved their quality in the world are marketed and distributed by BioTrend in Turkey.

CELLLINK 3D Bioprinting Technology

CELLLINK 3D Bioprinting Technology

 

Global Stem Cells Group announces that it will represent CELLINK Bioprinting Technology in Latin America. CELLINK is the world’s first company to market bioinks for 3D bioprinting of human organs and tissue.

MIAMI, Nov. 9, 2017—Global Stem Cells Group (GSCG), a world leader in stem cell and regenerative medicine, announces it will represent CELLLINK 3D Bioprinting Technology in Latin America. CELLINK is the world’s first company biotech company to market bioinks for 3D bioprinting of human organs and tissue.

GSCG will also market CELLINK’S newest product, BIO X printer for researchers, life science companies, and innovators who work with bioprinting on its subsidiary Adimarket.net website.

3D bioprinting of human tissues and organs is a revolutionary technology in the field of tissue engineering. One of the major challenges in stem cell research and tissue engineering is mimicking the micro and macro environment of human tissues. A favorable functional outcome is extremely dependent on the level to which tissue scientist and engineers are able to control the inner micro- and macro-scale features of engineered-tissue. In response to this challenge, advances in additive manufacturing inspired scientists to develop and adapt 3D bioprinting technology for human tissues and organs.

“Our objective is to bring this cutting-edge 3D bioprinting technology to scientists and regenerative medicine researcher throughout Lain America,” says Global Stem Cells Group founder and CEO Benito Novas. “CELLINK has revolutionized tissue engineering with its range of bioprinters, and we’re excited to make this process available to scientists and regenerative medicine researchers in Mexico, Central America, and South America.

“This opportunity is ideally suited to Global Stem Cells’ commitment to advancing the benefits of stem cell medicine in Latin America and worldwide, Novas says.”

To learn more about Global Stem Cells Group, visit the GSCG website,  email info@stemcellsgroup.com, or call +1305 560 5337.

About Global Stem Cells Group:

Global Stem Cells Group (GSCG) Global Stem Cells Group (GSCG) is a worldwide network that combines seven major medical corporations, each focused on furthering scientific and technological advancements to lead cutting-edge stem cell development, treatments, and training. The united efforts of GSCG’s affiliate companies provide medical practitioners with a one-stop hub for stem cell solutions that adhere to the highest medical standards.

Global stem cell’s mission is to be the largest recognized stem cell and regenerative medicine network in the world.

About AdiMarket:

Adimarket, Inc., a division of the Global Stem Cells Group, is a one-stop, cost-competitive online marketplace for quality regenerative medicine equipment and supplies for physicians and health care professionals.

Adimarket was founded to provide practitioners the tools they need to practice regenerative medicine in a medical office setting. Motivated by a firm belief in the impact stem cell medicine can have when dispensed in a doctor’s office, Adimarket provides physicians with the tools they need to provide patients with cutting-edge treatments.

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CELLLINK 3D bioprinting technology